<div id="readability-page-1">11:16 AM EST, 01/28/2026 (MT Newswires) -- European equities traded in the US as American depositary receipts fell sharply late Wednesday morning, dropping 1.35% to 1,820.75 on the S&amp;P Europe Select ADR Index.From continental Europe, the gainers were led by internet browser company Opera (OPRA) and accommodations booking site trivago (TRVG), which rose 4.1% and 0.7% respectively. They were followed by software firm SAP (SAP) and internet advertising firm Criteo ( CRTO ) , which were up 0.6% and 0.3% respectively.The decliners from continental Europe were led by biopharmaceutical company Cellectis ( CLLS ) and pharmaceutical company Ascendis Pharma ( ASND ) , which fell 4% and 3.8% respectively. They were followed by biotech firm Evaxion ( EVAX ) and lender Banco Bilbao Vizcaya Argentaria ( BBVA ) , which were down 3.7% and 3.4% respectively.From the UK and Ireland, the gainers were led by insurance firm Prudential (PUK) and alcoholic beverage company Diageo ( DEO ) , which advanced 1.4% and 0.9%, respectively. They were followed by educational publisher Pearson (PSO), which increased 0.7%.The decliners from the UK and Ireland were led by biopharmaceutical companies Bicycle Therapeutics ( BCYC ) and Biodexa Pharmaceuticals ( BDRX ) , which dropped 5.1% and 4.8% respectively. They were followed by biotech firm Trinity Biotech ( TRIB ) and biopharmaceutical company Mereo BioPharma Group ( MREO ) , which lost 2.6% and 2% respectively. MT Newswires does not provide investment advice. Unauthorized reproduction is strictly prohibited.</div>

BCYC

BDRX

TRVG

ASND

OPRA

European equities traded in the US saw a sharp decline in American depositary receipts, dropping 1.35% to 1,820.75 on the S&P Europe Select ADR Index. Notable gainers included Opera (up 4.1%) and trivago (up 0.7%), while Cellectis and Ascendis Pharma led the decliners, falling 4% and 3.8%, respectively. In the UK and Ireland, Prudential and Diageo were among the gainers, while Bicycle Therapeutics and Biodexa Pharmaceuticals faced significant losses of 5.1% and 4.8%.

fidelity

Diageo

Diageo plc

Bicycle Therapeutics

Biodexa Pharmaceuticals

Prudential

Trivago NV

Ascendis Pharmac

Opera

European Equities Traded in the US as American Depositary Receipts Fall Sharply in Wednesday Trading